Volume 21, Issue 8

open access Global reach, higher impact

Volume 21 (8); 2025

Research Papers

Pterostilbene Induces Apoptosis in Awakening Quiescent Prostate Cancer Cells by Upregulating C/EBP-β-Mediated SOD2 Transcription
Zhichao Xi, Mengfan Liu, Xue Jiang, Jiling Feng, Rongchen Dai, Wan Najbah Nik Nabil, Xueyang Sun, Jiayi Chen, Hangui Ren, Juan Zhang, Qihan Dong, Man Yuan, Yang Li, Hongxi Xu
Int. J. Biol. Sci. 2025; 21(8): 3379-3396. doi:10.7150/ijbs.106219
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Luteolin improves precancerous conditions of the gastric mucosa by binding STAT3 and inhibiting LCN2 expression
Xinyu Hao, Shouli Yuan, Jing Ning, Yuanfei Zhou, Yanfei Lang, Xiurui Han, Qiao Meng, Ying Xiong, Rongli Cui, Yueqing Gong, Chao Ma, Weichao Xu, Yangang Wang, Xiaohuan Guo, Chu Wang, Jing Zhang, Weiwei Fu, Shigang Ding
Int. J. Biol. Sci. 2025; 21(8): 3397-3415. doi:10.7150/ijbs.111636
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Exploring Negative Feedback Mechanisms in the PTEN-ACE Axis: Application of Electrosorb Hydrogel-Based Gene Delivery for Intervertebral Disc Regeneration
Youfeng Guo, Feng Wang, Yu Zhou, Bijun Wang, Chao Wang, Tao Hu, Desheng Wu
Int. J. Biol. Sci. 2025; 21(8): 3416-3443. doi:10.7150/ijbs.111898
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Endothelial SIRT3 deficiency predisposes brown adipose tissue to whitening in diet-induced obesity
Qing Zhou, Zongshi Lu, Bowen Wang, Yuyan Wang, Li Li, Mei You, Lijuan Wang, Tingbing Cao, Dan Tong, Jie Xiang, Yu Zhao, Qiang Li, Aidi Mou, Wentao Shu, Hongbo He, Zhigang Zhao, Daoyan Liu, Zhiming Zhu, Peng Gao, Zhencheng Yan
Int. J. Biol. Sci. 2025; 21(8): 3444-3460. doi:10.7150/ijbs.110741
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Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway
Yuan Xie, Ying Tian, Junting Huang, Wanying Deng, Xiaohui Li, Yujia Liu, Hao Liu, Lei Gao, Qiu Xie, Qi Yu
Int. J. Biol. Sci. 2025; 21(8): 3505-3526. doi:10.7150/ijbs.104778
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Radio-chemotherapy and metformin selectively modulate the heterogeneous landscape of glioma with ribosome biogenesis, long non coding RNA and immune-escape markers as major player
Silvia Valtorta, Silvia Granata, Stefano de Pretis, Gloria Bertoli, Serena Redaelli, Valeria Berno, Antonello E. Spinelli, Santo Diprima, Paolo Rainone, Angela Coliva, Sergio Todde, Giovanni Marfia, Stefania Navone, Manuela Caroli, Angela Bentivegna, Nadia Di Muzio, Rosa Maria Moresco
Int. J. Biol. Sci. 2025; 21(8): 3527-3554. doi:10.7150/ijbs.103194
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Identification of a Novel Small Molecule STING Agonist Reshaping the Immunomicroenvironment of Pancreatic Ductal Adenocarcinoma
Pengyi Liu, Minmin Shi, Yang Liu, Yihao Liu, Jiayu Lin, Shuyu Zhai, Yizhi Cao, Dongjie Chen, Yongsheng Jiang, Chenghong Peng, Lei Zhang, Chunyong Ding, Lingxi Jiang, Baiyong Shen
Int. J. Biol. Sci. 2025; 21(8): 3555-3572. doi:10.7150/ijbs.107837
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Integrative Single-Cell and Spatial Transcriptomics Analysis Reveals ECM-remodeling Cancer-associated Fibroblast-Derived POSTN as a Key Mediator in Pancreatic Ductal Adenocarcinoma Progression
Yifan Wu, Shuquan Li, Hao Yu, Sha Zhang, Liang Yan, Xiaoya Guan, Wei Xu, Zhen Wang, Ang Lv, Xiuyun Tian, Chunyi Hao, Jianhui Wu
Int. J. Biol. Sci. 2025; 21(8): 3573-3596. doi:10.7150/ijbs.108618
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TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis
Yongyun Chang, Keyu Kong, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Jingwei Zhang, Yansong Qi, Yongsheng Xu, An Qin, Zanjing Zhai, Huiwu Li
Int. J. Biol. Sci. 2025; 21(8): 3597-3613. doi:10.7150/ijbs.108832
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Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis
Balaji Chandrasekaran, Bhawna Tyagi, Ashish Tyagi, Vaibhav Shukla, Mollie Schatz, Thulasidharan Nair Devanarayanan, Neha Tyagi, Chendil Damodaran
Int. J. Biol. Sci. 2025; 21(8): 3614-3630. doi:10.7150/ijbs.110174
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Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy
Wei Fu, Shu-chang Liu, Tong-xiang Xu, Ying Liu, Teng Zhang, Dong-jie Liu, Xiao Wang, Jian-yao Wang, Yu-xin He, Tao Ma
Int. J. Biol. Sci. 2025; 21(8): 3631-3648. doi:10.7150/ijbs.110904
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PARP inhibitor augments anti-tumor efficacy of DNMT inhibitor by inducing senescence in cholangiocarcinoma
Peili Wang, Rong Xiao, Jianfeng Chen, Peiyong Guan, Hong Lee Heng, Lizhen Liu, Yali Wang, Xian Zeng, Guixiang Zhong, Jing Hao, Jiuping Gao, Jason Yongsheng Chan, Simona Dima, Choon Kiat Ong, Bin Tean Teh, Mei Li, Jing Han Hong, Jing Tan
Int. J. Biol. Sci. 2025; 21(8): 3649-3665. doi:10.7150/ijbs.110947
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MNX1-AS1 suppresses chemosensitivity by activating the PI3K/AKT pathway in breast cancer
You Shuai, Zhonghua Ma, Jian Yue, Chunxiao Li, Jie Ju, Xue Wang, Haili Qian, Peng Yuan
Int. J. Biol. Sci. 2025; 21(8): 3689-3704. doi:10.7150/ijbs.104483
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ITLN1 exacerbates Crohn's colitis by driving ZBP1-dependent PANoptosis in intestinal epithelial cells through antagonizing TRIM8-mediated CAPN2 ubiquitination
Jie Zhao, Yujiang Li, Pu Ying, Yan Zhou, Ziwei Xu, Dongmei Wang, Honggang Wang, Liming Tang
Int. J. Biol. Sci. 2025; 21(8): 3705-3725. doi:10.7150/ijbs.105550
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Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression
Yat-Yin Law, Haritha Rengamanar, Chih-Ying Wu, Chih-Chuang Liaw, Shubham Suresh Ghule, Yu-Ying Wu, Kuan-Ying Lai, Le Huynh Hoai Thuong, Trung-Loc Ho, Athena Yanjen Lin, Yi-Chin Fong, Chun-Hao Tsai, Chih-Hsin Tang
Int. J. Biol. Sci. 2025; 21(8): 3740-3754. doi:10.7150/ijbs.111356
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METTL3 mediated m6A modification of HKDC1 promotes renal injury and inflammation in lead nephropathy
Xiao-guo Suo, Jia-nan Wang, Qi Zhu, Meng-meng Zhang, Qing-lin Ge, Li-jin Peng, Yue-yue Wang, Ming-lu Ji, Yang-mei Ou, Ju-tao Yu, Hao Lu, Xin-ran Cheng, Bing-bing Hou, Xin Chen, Sai Zhu, Xiang-yu Li, Chao Li, Shuai-shuai Xie, Chen Yang, Feng-he Li, Juan Jin, Fang Wang, Xiao-ming Meng
Int. J. Biol. Sci. 2025; 21(8): 3755-3775. doi:10.7150/ijbs.112463
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Cyclophilin J Reprograms Tumor-associated Macrophages to Exert an Anti-tumor Effect in Liver Cancer
Jing Wang, Chen Yao, Qi Zeng, Lixia Peng, Shimeng Zhang, Yizhi Mao, Lingyi Fu, Shuai Chen, Chunjie Sheng
Int. J. Biol. Sci. 2025; 21(8): 3776-3790. doi:10.7150/ijbs.113197
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Reviews

Heart failure, inflammation and exercise
Qian Luo, Qing Zhang, Youli Kong, Shiqi Wang, Quan Wei
Int. J. Biol. Sci. 2025; 21(8): 3324-3350. doi:10.7150/ijbs.109917
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HSF1 Activation Mechanisms, Disease Roles, and Small Molecule Therapeutics
Bingwei Zhang, Yumei Fan, Ke Tan
Int. J. Biol. Sci. 2025; 21(8): 3351-3378. doi:10.7150/ijbs.110447
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The Lung-Brain Axis in Chronic Obstructive Pulmonary Disease-Associated Neurocognitive Dysfunction: Mechanistic Insights and Potential Therapeutic Options
Xiao Yu, Hui Xiao, Yushan Liu, Zhiyong Dong, Xiaoting Meng, Fang Wang
Int. J. Biol. Sci. 2025; 21(8): 3461-3477. doi:10.7150/ijbs.109261
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Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives
Wenwen Yang, Yanting Cao, Jiayan Li, Xin Zhang, Xiaoyi Liu, Ye Tian, Liang Shan, Yang Yang
Int. J. Biol. Sci. 2025; 21(8): 3478-3504. doi:10.7150/ijbs.111288
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Omics-based Approach Towards Macrophages: New Perspectives of Biology and Function in the Normal and Diseased Heart
Chao Yang, Huajun Li, Yuxing Chen, Wei Zhu, Jianan Wang
Int. J. Biol. Sci. 2025; 21(8): 3666-3688. doi:10.7150/ijbs.112061
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Regulatory Action of Calcium and Calcium Channels in Pain Pathways
Yan Zhang, John Shannonhouse, Hyeonwi Son, Joon Tae Park, Yu Shin Kim
Int. J. Biol. Sci. 2025; 21(8): 3726-3739. doi:10.7150/ijbs.110504
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Exosomes: a promising microenvironment modulator for spinal cord injury treatment
Yanming Ma, Xiaojun Yu, Jingxin Pan, Yingguang Wang, Ruoyu Li, Xiaodong Wang, Huimin Hu, Dingjun Hao
Int. J. Biol. Sci. 2025; 21(8): 3791-3824. doi:10.7150/ijbs.115242
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Erratum

The inhibition of YTHDF3/m⁶A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer: Erratum
Sheng Zhong, Quanwei Guo, Xiaona Chen, Xiaomin Luo, Yufei Long, Tuotuo Chong, Ming Ye, Hui He, Anwei Lu, Keyi Ao, Minuo Yin, Aimin Xu, Xin Li, Yi Hao, Xia Guo
Int. J. Biol. Sci. 2025; 21(8): 3825-3826. doi:10.7150/ijbs.115928
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