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Volume 17 (8); 2021

Research Papers

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Could protein content of Urinary Extracellular Vesicles be useful to detect Cirrhosis in Alcoholic Liver Disease?
Esperanza Gonzalez, Mikel Azkargorta, Clara Garcia-Vallicrosa, Janire Prieto-Elordui, Felix Elortza, Sonia Blanco-Sampascual, Juan Manuel Falcon-Perez
Int. J. Biol. Sci. 2021; 17(8): 1864-1877. doi:10.7150/ijbs.59725
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners
Zhen-Zhen Lai, Hui-Li Yang, Jia-Wei Shi, Hui-Hui Shen, Yan Wang, Kai-Kai Chang, Tao Zhang, Jiang-Feng Ye, Jian-Song Sun, Xue-Min Qiu, Ming-Qing Li
Int. J. Biol. Sci. 2021; 17(8): 1878-1894. doi:10.7150/ijbs.58657
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells
Jae Hyeon Park, Amit Kundu, Su Hyun Lee, ChunXue Jiang, Song Hee Lee, Ye Seul Kim, So Young Kyung, So Hyun Park, Hyung Sik Kim
Int. J. Biol. Sci. 2021; 17(8): 1895-1908. doi:10.7150/ijbs.59855
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1
Feng-Nan Li, Qin-Yi Zhang, Ou Li, Shi-Lei Liu, Zi-Yi Yang, Li-Jia Pan, Cheng Zhao, Wei Gong, Yi-Jun Shu, Ping Dong
Int. J. Biol. Sci. 2021; 17(8): 1909-1924. doi:10.7150/ijbs.57623
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation
Qian Tang, Yue Wang, Ling Ou, Jieling Li, Kai Zheng, Hui Zhan, Jiayu Gu, Guibao Zhou, Shouxia Xie, Jianping Zhang, Wei Huang, Shaoxiang Wang, Xiao Wang
Int. J. Biol. Sci. 2021; 17(8): 1925-1939. doi:10.7150/ijbs.57802
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MicroRNA-135b/CAMK2D Axis Contribute to Malignant Progression of Gastric Cancer through EMT Process Remodeling
Longtao Huangfu, Qifei He, Jing Han, Jingyao Shi, Xiaomei Li, Xiaojing Cheng, Ting Guo, Hong Du, Wanhong Zhang, Xiangyu Gao, Fengming Luan, Xiaofang Xing, Jiafu Ji
Int. J. Biol. Sci. 2021; 17(8): 1940-1952. doi:10.7150/ijbs.58062
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo/YAP1 pathway in colorectal cancer
Huihui Wang, Hao Zhang, Zhirong Sun, Wankun Chen, Changhong Miao
Int. J. Biol. Sci. 2021; 17(8): 1953-1962. doi:10.7150/ijbs.58135
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA EPB41L4A-AS2 represses Nasopharyngeal Carcinoma Metastasis by binding to YBX1 in the Nucleus and Sponging MiR-107 in the Cytoplasm
Mingyu Du, Xinyu Hu, Xuesong Jiang, Li Yin, Jie Chen, Jing Wen, Yanxin Fan, Fanyu Peng, Luxi Qian, Jing Wu, Xia He
Int. J. Biol. Sci. 2021; 17(8): 1963-1978. doi:10.7150/ijbs.55557
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription
Pingfu Hou, Tian Lin, Sen Meng, Meilin Shi, Fang Chen, Tao Jiang, Zhongwei Li, Minle Li, Sufang Chu, Junnian Zheng, Jin Bai
Int. J. Biol. Sci. 2021; 17(8): 1979-1994. doi:10.7150/ijbs.58422
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer
Rui Bai, Cheng Yuan, Wenjie Sun, Jianguo Zhang, Yuan Luo, Yanping Gao, Yangyi Li, Yan Gong, Conghua Xie
Int. J. Biol. Sci. 2021; 17(8): 1995-2008. doi:10.7150/ijbs.59019
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation of dmrt1 in Monopterus albus
Fengling Lai, Yibin Cheng, Juan Zou, Haoyu Wang, Wang Zhu, Xin Wang, Hanhua Cheng, Rongjia Zhou
Int. J. Biol. Sci. 2021; 17(8): 2009-2020. doi:10.7150/ijbs.59347
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The effect of mitochondrial transplantation therapy from different gender on inhibiting cell proliferation of malignant melanoma
Zhenyao Yu, Yixue Hou, Wei Zhou, Zizhen Zhao, Zesheng Liu, Ailing Fu
Int. J. Biol. Sci. 2021; 17(8): 2021-2033. doi:10.7150/ijbs.59581
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Livin in synergy with Ras induces and sustains corticosteroid resistance in the airway mucosa
Jin-Mei Xue, Yun-Fang An, Li-Min Suo, Li-Hua Mo, Gui Yang, Xiang-Qian Luo, Da-Bo Liu, Chang-Qing Zhao, Ping-Chang Yang
Int. J. Biol. Sci. 2021; 17(8): 2089-2098. doi:10.7150/ijbs.58427
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MiR-124 Negatively Regulated PARP1 to Alleviate Renal Ischemia-reperfusion Injury by Inhibiting TNFα/RIP1/RIP3 Pathway
Jing Ke, Fan Zhao, Yanwen Luo, Fangjing Deng, Xiongfei Wu
Int. J. Biol. Sci. 2021; 17(8): 2099-2111. doi:10.7150/ijbs.58163
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inflammation characteristics and anti-inflammation treatment with tocilizumab of severe/critical COVID-19 patients: A retrospective cohort study
Qin Hu, Yu Xu, Ying Xiang, Bin Wang, Zhiquan Yuan, Yifan Shan, Wenjing Zhang, Na Wu, Tingting Xia, Chengying Li, Weijia Xie, Xiaoyue Jia, Zubin Yu, Li Bai, Yafei Li
Int. J. Biol. Sci. 2021; 17(8): 2124-2134. doi:10.7150/ijbs.56952
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
Li Li, Cheng Chen, Chengyao Chiang, Tian Xiao, Yangchao Chen, Yongxiang Zhao, Duo Zheng
Int. J. Biol. Sci. 2021; 17(8): 2034-2049. doi:10.7150/ijbs.59918
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
Xiaoxuan Ma, Zhenghong Liu, Iqra Ilyas, Peter J. Little, Danielle Kamato, Amirhossein Sahebka, Zhengfang Chen, Sihui Luo, Xueying Zheng, Jianping Weng, Suowen Xu
Int. J. Biol. Sci. 2021; 17(8): 2050-2068. doi:10.7150/ijbs.59965
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Progress of Breast Cancer basic research in China
Xuerong Wang, Chao Wang, Jiaheng Guan, Baoan Chen, Lin Xu, Ceshi Chen
Int. J. Biol. Sci. 2021; 17(8): 2069-2079. doi:10.7150/ijbs.60631
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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COVID-19 one year later: a retrospect of CRISPR-Cas system in combating COVID-19
Yan Zhan, Xiang-Ping Li, Ji-Ye Yin
Int. J. Biol. Sci. 2021; 17(8): 2080-2088. doi:10.7150/ijbs.60655
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Roles of microRNAs in inflammatory bowel disease
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Int. J. Biol. Sci. 2021; 17(8): 2112-2123. doi:10.7150/ijbs.59904
[Abstract] [Full text] [PDF] [PubMed] [PMC]