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Volume 17 (7); 2021

Research Papers

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Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway
Guangjie Ji, Shiming He, Cong Huang, Yanqing Gong, Xuesong Li, Liqun Zhou
Int. J. Biol. Sci. 2021; 17(7): 1613-1628. doi:10.7150/ijbs.59559
[Abstract] [Full text] [PDF]


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YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis
Tianqi Zhang, Maneesh Kumarsing Beeharry, Zhenqiang Wang, Zhenggang Zhu, Jianfang Li, Chen Li
Int. J. Biol. Sci. 2021; 17(7): 1629-1643. doi:10.7150/ijbs.58921
[Abstract] [Full text] [PDF]


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Wnt/β-catenin Signaling Inhibitors suppress the Tumor-initiating properties of a CD44+CD133+ subpopulation of Caco-2 cells
Junghoon Kim, Kyeng-Won Choi, Jungwoon Lee, Jaeyoung Lee, Seonock Lee, Ruijing Sun, Jungho Kim
Int. J. Biol. Sci. 2021; 17(7): 1644-1659. doi:10.7150/ijbs.58612
[Abstract] [Full text] [PDF]


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CHD4 as an important mediator in regulating the malignant behaviors of colorectal cancer
Chia-Lo Chang, Chi-Ruei Huang, Shu-Jyuan Chang, Chun-Chieh Wu, Hong-Hwa Chen, Chi-Wen Luo, Hon-Kan Yip
Int. J. Biol. Sci. 2021; 17(7): 1660-1670. doi:10.7150/ijbs.56976
[Abstract] [Full text] [PDF]


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MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer
Yuan Luo, Shijing Ma, Yingming Sun, Shan Peng, Zihang Zeng, Linzhi Han, Shuying Li, Wenjie Sun, Jieyu Xu, Xiaoli Tian, Feng Wang, Qiuji Wu, Yu Xiao, Junhong Zhang, Yan Gong, Conghua Xie
Int. J. Biol. Sci. 2021; 17(7): 1671-1681. doi:10.7150/ijbs.57964
[Abstract] [Full text] [PDF]


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Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver
Muyu Yu, Miriayi Alimujiang, Lili Hu, Fang Liu, Yuqian Bao, Jun Yin
Int. J. Biol. Sci. 2021; 17(7): 1693-1707. doi:10.7150/ijbs.54604
[Abstract] [Full text] [PDF]


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NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity
Batuer Aikemu, Yanfei Shao, Guang Yang, Junjun Ma, Sen Zhang, Xiao Yang, Hiju Hong, Galiya Yesseyeva, Ling Huang, Hongtao Jia, Chenxing Wang, Lu Zang, Jing Sun, Minhua Zheng
Int. J. Biol. Sci. 2021; 17(7): 1716-1730. doi:10.7150/ijbs.56694
[Abstract] [Full text] [PDF]


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LRP1B mutation is associated with tumor HPV status and promotes poor disease outcomes with a higher mutation count in HPV-related cervical carcinoma and head & neck squamous cell carcinoma
Can-hui Cao, Rang Liu, Xin-ran Lin, Jia-qi Luo, Li-juan Cao, Qiu-ju Zhang, Shou-ren Lin, Lan Geng, Zhong-yi Sun, Si-kang Ye, Zhi-ying Yu, Yu Shi, Xi Xia
Int. J. Biol. Sci. 2021; 17(7): 1744-1756. doi:10.7150/ijbs.56970
[Abstract] [Full text] [PDF]


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Long Noncoding RNA KCNQ1OT1 is a Prognostic Biomarker and mediates CD8+ T cell exhaustion by regulating CD155 Expression in Colorectal Cancer
Zheng-bin Lin, Pei Long, Zhan Zhao, Yi-ran Zhang, Xiao-dong Chu, Xiao-xu Zhao, Hui Ding, Song-wei Huan, Yun-long Pan, Jing-hua Pan
Int. J. Biol. Sci. 2021; 17(7): 1757-1768. doi:10.7150/ijbs.59001
[Abstract] [Full text] [PDF]


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Biological and Physiochemical Methods of Biofilm Adhesion Resistance Control of Medical-Context Surface
Yuanzhe Li, Xiang Li, Yu Hao, Yang Liu, ZhiLi Dong, Kexin Li
Int. J. Biol. Sci. 2021; 17(7): 1769-1781. doi:10.7150/ijbs.59025
[Abstract] [Full text] [PDF]


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Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis
Xiang Li, Chang Yu, Yichun Luo, Jiacheng Lin, Fang Wang, Xuehua Sun, Yueqiu Gao, Weifeng Tan, Qiang Xia, Xiaoni Kong
Int. J. Biol. Sci. 2021; 17(7): 1782-1794. doi:10.7150/ijbs.59068
[Abstract] [Full text] [PDF]


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MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis
Chunlu Li, Chengsi Deng, Tingting Zhou, Jiapeng Hu, Bing Dai, Fei Yi, Na Tian, Lijun Jiang, Xiang Dong, Qingfeng Zhu, Siyi Zhang, Hongyan Cui, Liu Cao, Yunxiao Shang
Int. J. Biol. Sci. 2021; 17(7): 1795-1807. doi:10.7150/ijbs.59715
[Abstract] [Full text] [PDF]


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ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway
Wen-Kuan Huang, Yi Chen, Huafang Su, Tung-Ying Chen, Jiwei Gao, Yaxuan Liu, Chun-Nan Yeh, Shuijie Li
Int. J. Biol. Sci. 2021; 17(7): 1808-1820. doi:10.7150/ijbs.55919
[Abstract] [Full text] [PDF]


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Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis
Feng Wang, Huijuan Qian, Lingchi Kong, Wenbo Wang, Xiaoyu Wang, Ze Xu, Yimin Chai, Jia Xu, Qinglin Kang
Int. J. Biol. Sci. 2021; 17(7): 1821-1836. doi:10.7150/ijbs.57681
[Abstract] [Full text] [PDF]

Reviews

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Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development
Jiju Li, Yangli Pei, Rong Zhou, Zhonglin Tang, Yalan Yang
Int. J. Biol. Sci. 2021; 17(7): 1682-1692. doi:10.7150/ijbs.56251
[Abstract] [Full text] [PDF]


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Splicing factor SRSF2-centric gene regulation
Kun Li, Ziqiang Wang
Int. J. Biol. Sci. 2021; 17(7): 1708-1715. doi:10.7150/ijbs.58888
[Abstract] [Full text] [PDF]


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The emerging function and clinical significance of circRNAs in Thyroid Cancer and Autoimmune Thyroid Diseases
Yu Zhang, Dong-Dong Jia, Yi-Fei Zhang, Meng-Die Cheng, Wen-Xiu Zhu, Pei-Feng Li, Yin-Feng Zhang
Int. J. Biol. Sci. 2021; 17(7): 1731-1741. doi:10.7150/ijbs.55381
[Abstract] [Full text] [PDF]

Erratum

Long noncoding RNA LINC01123 promotes the proliferation and invasion of hepatocellular carcinoma cells by modulating the miR-34a-5p/TUFT1 axis: Erratum
Zunqiang Xiao, Yang Liu, Junjun Zhao, Lijie Li, Linjun Hu, Qiliang Lu, Zhi Zeng, Xin Liu, Dongsheng Huang, Wei Yang, Qiuran Xu
Int. J. Biol. Sci. 2021; 17(7): 1742-1743. doi:10.7150/ijbs.61130
[Abstract] [Full text] [PDF]