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Volume 21 (12); 2025

Research Papers

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Recovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol-induced neurodegeneration
Jae Ryong Lim, Chang Woo Chae, Jee Hyeon Yoon, Ji Hyeon Cho, Ji Yong Park, Su Jong Han, Han Seung Chang, Su Yeol Kim, Ha Jin Kim, Young Hyun Jung, Ho Jae Han
Int. J. Biol. Sci. 2025; 21(12): 5167-5184. doi:10.7150/ijbs.116673
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Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway
Yu-Xing Liu, Hao Huang, Fang Wang, Mei-Fang Zhao, Jie-Yuan Jin, Yi Dong, Qian Wang, Liang-Liang Fan, Rong Xiang
Int. J. Biol. Sci. 2025; 21(12): 5185-5205. doi:10.7150/ijbs.110125
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ANXA6 Overexpression Causes Abnormal Decidual Macrophage-Trophoblast Crosstalk in Recurrent Spontaneous Abortion
Xin Chen, Xue Yao Li, Xue Qin Ma, Yan Zhang, Qian Lin Song, Jing Yang
Int. J. Biol. Sci. 2025; 21(12): 5206-5222. doi:10.7150/ijbs.111791
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Targeting NINJ1-Mediated Plasma Membrane Rupture in Tubular Epithelial Cell Prevents Inflammatory Response in Acute Kidney Injury
Siyan Zhou, Qigang Lan, Wang Xin, Yaqin Wang, Aihong Zhang, Jiachuan Xiong, Liangjing Lv, Yan Li, Ling Nie, Shaozong Qin, Jinrun Zhou, Shuiqin Gong, Shaobo Wang, Yinghui Huang, Jinghong Zhao
Int. J. Biol. Sci. 2025; 21(12): 5223-5239. doi:10.7150/ijbs.115364
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Senescent Tumoral HLA-E Reshapes Microenvironment through Impairing NK Cell-Dendritic Cell-T Cell Network in Malignant Pleural Effusion from Lung Cancer
Ying-Ming Tsai, Jen-Yu Hung, Yu-Yuan Wu, Hung-Pei Tsai, Kuan-Li Wu, Tai-Huang Lee, Hung-Hsing Chiang, Wei-An Chang, Hsiao-Chen Lee, Sheng-Feng Pan, Kai-Chien Chuang, Shu-Fang Jian, Ling-Yu Wu, Ya-Ling Hsu
Int. J. Biol. Sci. 2025; 21(12): 5240-5257. doi:10.7150/ijbs.116499
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Dectin-1 is Pathogenic in Chronic Kidney Disease by Promoting Macrophage Infiltration and Transition to Myofibroblast
Lingling Shen, Jingyi Li, Anqi Zhang, Sijing Yan, Wenxin Sha, Yucheng Wang, Shi Feng, Cuili Wang, Zhimin Chen, Hongfeng Huang, Bingjue Li, Pingping Ren, Suhan Zhou, Siqi Wu, Yanli Wang, Zhouji Shen, Song Rong, Hermann Haller, Hong Jiang, Jianghua Chen
Int. J. Biol. Sci. 2025; 21(12): 5287-5304. doi:10.7150/ijbs.119129
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Comprehensive analytical approach identifies a subtype of CTCF+ tumor-associated neutrophils associated with CRC development and as a biomarker for immunotherapy
Jie-pin Li, Yuan-jie Liu, Yi Zhang, Qian-wen Ye, Guo Xu, Jin-chen Chong, Yi Yin, Yang Li, Shuang-shuang Wang, Jin-yong Zhou, Jun Qian, Shen-lin Liu, Xi Zou, Yu-gen Chen
Int. J. Biol. Sci. 2025; 21(12): 5305-5327. doi:10.7150/ijbs.111529
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E3 ligase MKRN2 destabilizes PPP2CA proteins to inactivate canonical Wnt pathway and mitigates tumorigenesis of clear cell renal cell carcinoma
Tiexi Yu, Weiquan Li, Xiangui Meng, Hongwei Yuan, Hailong Ruan, Wen Xiao, Xiaoping Zhang
Int. J. Biol. Sci. 2025; 21(12): 5361-5377. doi:10.7150/ijbs.107130
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Altered Heme and Redox Homeostasis Underpin Late-onset Alzheimer's Disease
Adedamola Saidi Soladogun, Chantal Vidal, Maria Del Carmen Chacon Castro, Heng Du, Li Zhang
Int. J. Biol. Sci. 2025; 21(12): 5393-5410. doi:10.7150/ijbs.116204
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Therapeutic Activation of PPARα Inhibits Transformed Follicular Lymphoma Tumorigenesis via the FOXM1 Signaling Pathway
Dongmei Qin, Hui Zhou, Jie Zhou, Chendi Xie, Shuman Jia, Xingxing Yu, Yan Hong, Li Zhang, Yueting Huang, Yong Zhou, Bing Xu, Jie Zha
Int. J. Biol. Sci. 2025; 21(12): 5411-5427. doi:10.7150/ijbs.116437
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WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production
Qianqian Xu, Jing Zhang, Yuan Zou, Longmin Chen, Fei Sun, Xi Luo, Ting Wang, Yang Li, Shu Zhang, Fei Xiong, Qilin Yu, Ping Yang, Quan Gong, Shi-Wei Liu, Cong-Yi Wang
Int. J. Biol. Sci. 2025; 21(12): 5428-5443. doi:10.7150/ijbs.115672
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CLDN6 induces chemoresistance through protective autophagy in breast cancer
Huinan Qu, Qiu Jin, Mingzi Zhang, Da Qi, Minghao Sun, Yuan Dong, Chengshi Quan
Int. J. Biol. Sci. 2025; 21(12): 5444-5459. doi:10.7150/ijbs.116340
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JPI-547, a Dual Inhibitor of PARP/Tankyrase, Shows Antitumor Activity Against Pancreatic Cancers with Homologous Recombination Repair Deficiency or Wnt-Addiction
Kyoung-Seok Oh, Ah-Rong Nam, Ju-Hee Bang, Yoojin Jeong, Sea Young Choo, Hyo Jung Kim, Su In Lee, Jae-Min Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh
Int. J. Biol. Sci. 2025; 21(12): 5460-5475. doi:10.7150/ijbs.113726
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Increased CAPG inhibits ferroptosis to drive tumor proliferation and sorafenib resistance in hepatocellular carcinoma via the WDR74-p53-SLC7A11 pathway
Bing Quan, Fan Yao, Wenfeng Liu, Bei Tang, Miao Li, Shenxin Lu, Jinghuan Li, Rongxin Chen, Zhenggang Ren, Xin Yin
Int. J. Biol. Sci. 2025; 21(12): 5476-5495. doi:10.7150/ijbs.111419
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PGK1 Regulates Oxidative Stress in Gestational Diabetes Mellitus through the Estradiol-Keap1-Nrf2 Pathway
You Peng, Hengli Zhao, Jun Chen, Chi Chiu Wang, Tao Zhang, Tsz Ching Yeung, Haotong Ouyang, Jiayu Zhu, Xiangli Chen, Meng Li, Haoyue Hu, Mei Zhong
Int. J. Biol. Sci. 2025; 21(12): 5496-5513. doi:10.7150/ijbs.113728
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Overcoming Ferroptosis-Induced Exhaustion of NK Cells through Inhibition of the ATF3-Mediated Integrated Stress Response in Ovarian Cancer
Tian Chen, Shulin Zhou, Yashuang Zhang, Huangyang Meng, Huixian Miao, Mingming Feng, Yi Jiang, Yicong Wan, Lin Zhang, Wenjun Cheng
Int. J. Biol. Sci. 2025; 21(12): 5531-5546. doi:10.7150/ijbs.112615
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Activated B cells modulate the maturation of MDSCs via CD36-dependent MHC-II transfer to orchestrate CD4+ Th1-dominant antitumor immunity after cryo-thermal therapy
Zelu Zhang, Shicheng Wang, Junjun Wang, Yichen Yao, Yuankai Hao, Yue Lou, Ping Liu, Lisa X. Xu
Int. J. Biol. Sci. 2025; 21(12): 5547-5562. doi:10.7150/ijbs.115232
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DLGAP5 Promotes Acute Liver Injury via Hepatocyte Pyroptosis-Driven Macrophage Metabolic Reprogramming and M1 Polarization
Xianzhi Liu, Zhiyuan Chen, Jun Lin, Yifan Lian, Wenxuan Gan, Huajie Liu, Xingxiang Huang, Jiaxin Mei, Tianrong Ma, Zhi Lu, Wei Zeng, Yihang Gong, Shuai Chen, Weiling He
Int. J. Biol. Sci. 2025; 21(12): 5563-5585. doi:10.7150/ijbs.118024
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O-GlcNAcylated Hsp47 as a predictive biomarker in colorectal cancer: Kaempferol targets OGT-collagen axis for therapeutic intervention
Chishun Zhou, Jing Zheng, Zizheng Li, Yu Li, Xin Jin, Yukai Huang, Yuefang Lin, Xinyue Wen, Yin Wang, Jiarun Lin, Ying Wang, Wei Wang, Zhongqiu Liu, Linlin Lu
Int. J. Biol. Sci. 2025; 21(12): 5586-5608. doi:10.7150/ijbs.116513
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Reviews

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Recent Advances of Trained immunity in Macrophages
Peizhi Li, Manman Liu, Yakun Liu, Jing Guo, Jingfeng Jiang, Guidan Wang, Chenlong Cao, Xinru Wang, Junxing Qu, Zhiheng Sun
Int. J. Biol. Sci. 2025; 21(12): 5258-5283. doi:10.7150/ijbs.115515
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Mechanism of Ferroptosis and Its Role in Disease Development
Zhangruijian Ye, Bin Xie, Yongguang Tao, Desheng Xiao
Int. J. Biol. Sci. 2025; 21(12): 5328-5360. doi:10.7150/ijbs.102859
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Mitochondrial RNA in Inflammation
Jian Chen, Chen You, Haibo Xie, Qixing Zhu
Int. J. Biol. Sci. 2025; 21(12): 5378-5392. doi:10.7150/ijbs.119841
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FAM134B in Cellular Homeostasis: Bridging Endoplasmic Reticulum-Phagy to Human Diseases
Ning Chen, Jia-Qi Yang, Sen Tong, Lu Xu, Ning Dong, Yao Wu, Yu-Xuan Li, Ren-Qi Yao, Yong-Ming Yao
Int. J. Biol. Sci. 2025; 21(12): 5514-5530. doi:10.7150/ijbs.113890
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Commentaries

YBX1/CD36 positive feedback loop: novel molecular target for MASLD treatment
Yuxuan Jiang, Cristina Llorente
Int. J. Biol. Sci. 2025; 21(12): 5164-5166. doi:10.7150/ijbs.121866
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Comment on "IGF2BP3 promotes the proliferation and cisplatin resistance of bladder cancer by enhancing the mRNA stability of CDK6 in an m6A dependent manner"
Yongzheng Han, Chengming Li, Guangzhen Wu
Int. J. Biol. Sci. 2025; 21(12): 5284-5286. doi:10.7150/ijbs.120024
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