◂ Last issue Archive   

Volume 21 (11); 2025

Research Papers

Graphic abstract

TSG6 promotes epithelial-mesenchymal transition and tumor-associated macrophage polarization through Smad2/3 and MAPK signaling by facilitating TSG6-CD44-TGFβR1 or EGFR complex formation
Hyun-Ji Oh, Ga-Hong Min, Da-Eun Kim, Sol-bi Shin, Hyungshin Yim
Int. J. Biol. Sci. 2025; 21(11): 4701-4718. doi:10.7150/ijbs.115097
Full text PDF

Graphic abstract

Sesamin Induces MCL-1-Dependent Apoptosis in Activated T Cells and Ameliorates Experimental Atopic Dermatitis
Hee-Suk Park, Woo Jung Sung, Yoon-Yub Park, Jaewoo Hong, Hoon-Kyu Oh, Hyun-Su Lee
Int. J. Biol. Sci. 2025; 21(11): 4719-4735. doi:10.7150/ijbs.116753
Full text PDF

Graphic abstract

METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression
Jie Li, Qian Luo, Minjie Lu, Chen Lu, Caihong Xu, Jie Ding, Tian Zhan, Jing Zhu, Mengsen Qian, Shuhui Lin, Lisha Chang, Juan Li, Keming Wang
Int. J. Biol. Sci. 2025; 21(11): 4782-4797. doi:10.7150/ijbs.105391
Full text PDF

Graphic abstract

Histone Methyltransferase SETD1B Maintains Cancer Stem Cell Niche by Regulating the Crosstalk between CD24 and Surface Adhesion Molecules in Hepatocellular Carcinoma
Yan Gao, Wei Zhou, Yuehong Gao, Shunxi Wang, Zhiling Xu, Xiao Xiang, Li Yang
Int. J. Biol. Sci. 2025; 21(11): 4798-4815. doi:10.7150/ijbs.112943
Full text PDF

Graphic abstract

JCAD-Derived from Plasma Exosomes: Promoting Tumor Cell Progression and Predicting Poor Outcomes in Breast Cancer
Douwaner Liu, Min Xiong, Xiaoting Chen, Xuliren Wang, Yuting Sang, Shiyang Liu, Liyi Zhang, Weiru Chi, Hengyu Ren, Bingqiu Xiu, Qi Zhang, Yayun Chi, Jiong Wu, Jingyan Xue
Int. J. Biol. Sci. 2025; 21(11): 4816-4833. doi:10.7150/ijbs.107763
Full text PDF

Graphic abstract

Methylation-mediated LncRNA CRAT40 promotes colorectal cancer progression by recruiting YBX1 to initiate RelA transcription
Qing Lu, Xiuhe Lv, Jin Wang, Bihan Xia, Hailin Yan, Zhu Wang, Jinlin Yang
Int. J. Biol. Sci. 2025; 21(11): 4834-4850. doi:10.7150/ijbs.105629
Full text PDF

Graphic abstract

CREB Regulates Cisplatin Resistance by Targeting TNKS and KDM6A in NSCLC cell-Derived Tumor Spheroid
Ji Hae Lee, Youngjoo Kwon, Kyungsil Yoon
Int. J. Biol. Sci. 2025; 21(11): 4851-4871. doi:10.7150/ijbs.109419
Full text PDF

Graphic abstract

Hino-Fe Chelate Suppresses Osteosarcoma Progression through Dual Induction of Ferroptosis and NLRC4-mediated Pyroptosis: Mechanisms and Therapeutic Implications
Yuxing Chen, Yong Tao, Qiu Huang, Jingtao Xu, Zhenxin Wang, Ye Zhang, Guangxu Fu, Fuqiang Tan, Keyi Feng, Yunsheng Ou
Int. J. Biol. Sci. 2025; 21(11): 4872-4894. doi:10.7150/ijbs.113785
Full text PDF

Graphic abstract

A Small Molecule Selectively Targets N-Myc to Suppress Neuroblastoma Cancer Progression
Ying Miao, Huang Chen, Yuzhan Li, Liting Li, Jiangnan Ye, Jingwen Zhang, Jiayu Wang, Haigang Wu, Guihong Li, Yihua Chen, Zhengfang Yi, Mingyao Liu
Int. J. Biol. Sci. 2025; 21(11): 4895-4907. doi:10.7150/ijbs.97195
Full text PDF

Graphic abstract

N4-acetylcytidine modification of LINC02802 promotes non-small cell lung cancer progression by modulating mitochondrial NAD+/NADH ratio
Yixiao Yuan, Dahang Zhang, Juan Wang, Lin Tang, Yaowu Duan, Lincan Duan, Xiulin Jiang
Int. J. Biol. Sci. 2025; 21(11): 4908-4926. doi:10.7150/ijbs.116639
Full text PDF

Graphic abstract

MALAT1 promotes malignancy of HBV-related hepatocellular carcinoma by regulating IGF2BP3-mediated nuclear-cytoplasmic shuttling
Ze-Bang Du, Xin-Mou Wu, Tun Han, Yu-Xin Cai, Bo Qian, Yu-Shi Shen, Han-Yu Zhang, Jia-Shen Wu, Jie He, Xiao-Xuan Chen, Dong-Bei Guo, Hang-Tian Zhong, Xiong Li, Lei Zhang, Xiao-Ming Luo, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin
Int. J. Biol. Sci. 2025; 21(11): 4942-4960. doi:10.7150/ijbs.112133
Full text PDF

Graphic abstract

Blocking interplay between TERT and c-Myc: a new therapeutic strategy for BRAFV600E/pTERT double mutated tumors
Jing Wei, Jiazhe Liu, Yan Zhang, Guobin Wang, Xiao Cui, Wei Yu, Chunlei Nie, Peng Hou
Int. J. Biol. Sci. 2025; 21(11): 4961-4978. doi:10.7150/ijbs.111224
Full text PDF

Graphic abstract

PLK4 as a Key Regulator of Neuroblastoma Differentiation and a Promising Therapeutic Target
Xiangdong Tian, Yuren Xia, Wenchen Gong, Kangwei Zhu, Yulong Yang, Zhiqiang Han, Yun Liu, Jie Li, Xin Li, Yuchao He, Mingyou Gao, Lu Chen, Hua Guo, Qiang Zhao
Int. J. Biol. Sci. 2025; 21(11): 4979-4996. doi:10.7150/ijbs.111449
Full text PDF

Graphic abstract

Targeting the NAT10/XIST/YAP1 Axis-Mediated Vascular Abnormalization Enhances Immune Checkpoint Blockade in Gastric Cancer
Xuetao Lei, Boyang Zheng, Yanmei Peng, Guofan Zhang, Xia Cheng, Wenqiang Li, Jiayong He, Fengping Li, Ruoyu Ling, Ziyi Fu, Qingbin Yang, Gengtai Ye, Guoxin Li
Int. J. Biol. Sci. 2025; 21(11): 4997-5014. doi:10.7150/ijbs.113325
Full text PDF

Graphic abstract

Citrus Pectin Supplementation Alleviated Hepatic Lipid Accumulation through Gut Microbiota Indole Lactic Acid Promoting Hepatic Bile Acid Synthesis and Excretion
Zhijun Pan, Xinyuan Jin, Qing Li, Yuqing Zhou, Yupeng Zeng, Xin Wang, Yufeng Jin, Yu Chen, Dan Li, Wenhua Ling
Int. J. Biol. Sci. 2025; 21(11): 5015-5033. doi:10.7150/ijbs.116929
Full text PDF

Graphic abstract

Activation of sphingosine-1-phosphate receptors can relieve myocardial ischemia-reperfusion injury by mitigating oxidative stress and ferroptosis in cardiomyocytes
Xuan Xu, Runqian Li, Shengnan Li, Qin Wei, Fuchao Yu, Genshan Ma, Jiayi Tong
Int. J. Biol. Sci. 2025; 21(11): 5079-5096. doi:10.7150/ijbs.107402
Full text PDF

Graphic abstract

Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication
Xiangguang Shi, Xueyi Xia, Yang Xiao, Huizhen Shu, Zhuoya Xu, Mengguo Liu, Chenyi Shi, Ying Zhang, Yining Wei, Yiyi Gong, Wei Wang, Yahui Chen, Jianlan Liu, Jia Huang, Mengkun Shi, Jiucun Wang, Wenyu Wu
Int. J. Biol. Sci. 2025; 21(11): 5097-5115. doi:10.7150/ijbs.114930
Full text PDF

Reviews

Graphic abstract

The function of GPCRs in different bone cells
Yan Zhang, Nai-Ning Wang, Zi-Han Qiu, Jia-Hao Wang, Wen-Na An, Li-Dan Shi, Fei Chen, Da-Jin Zhang, Si-Yue Wang, Tie-Lin Yang, Shou-Ye Hu, Yan Guo
Int. J. Biol. Sci. 2025; 21(11): 4736-4761. doi:10.7150/ijbs.113585
Full text PDF

Graphic abstract

Mesangial Cells in Diabetic Kidney Disease: From Mechanisms to Therapeutic Implications
Li Feng, Yu-ying Feng, Qian Ren, Ping Fu, Liang Ma
Int. J. Biol. Sci. 2025; 21(11): 4762-4781. doi:10.7150/ijbs.114907
Full text PDF

Graphic abstract

Epigenetic orchestration of RNA m6A methylation in wound healing and post-wound events
Heao Zhang, Delong Gao, Zixin Li, Sis Aghayants, Yiping Wu, Zeming Liu, Qi Zhang
Int. J. Biol. Sci. 2025; 21(11): 4927-4941. doi:10.7150/ijbs.114988
Full text PDF

Graphic abstract

Lactate metabolic reprogramming and histone lactylation modification in sepsis
Ji Zhang, Dan Wu, Fu Zeng, Haiyun Gu, Chengbao Li, Juan P Cata, Kefang Guo, Changhong Miao, Hao Zhang
Int. J. Biol. Sci. 2025; 21(11): 5034-5055. doi:10.7150/ijbs.116088
Full text PDF

Graphic abstract

Innate Immunity Reimagined: Metabolic Reprogramming as a Gateway to Novel Therapeutics
Chuan-Han Deng, Chen-Tong Wang, Xin Zhou, Xin Chen, Ying Wang
Int. J. Biol. Sci. 2025; 21(11): 5056-5078. doi:10.7150/ijbs.114010
Full text PDF

Graphic abstract

siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention
Rahul Bhattacharjee, Debanjan Das, Srija Chakraborty, Radheka Bhaduri, Soham Chattopadhyay, Rajeev K Singla, Vinoth Kumarasamy, Rohit Gundamaraju
Int. J. Biol. Sci. 2025; 21(11): 5116-5134. doi:10.7150/ijbs.109637
Full text PDF

Graphic abstract

Roles of SIRT3 in aging and aging-related diseases
Yuzi You, Zhong Wang
Int. J. Biol. Sci. 2025; 21(11): 5135-5163. doi:10.7150/ijbs.115518
Full text PDF

Popup Image

©2025 Ivyspring International Publisher. Terms of use