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Volume 21 (10); 2025

Research Papers

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Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer
Yuxin Xie, Huiling Li, Jian Pan, Yijian Li, Dongshan Zhang
Int. J. Biol. Sci. 2025; 21(10): 4293-4311. doi:10.7150/ijbs.117443
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Stabilization of OLFML1 via m6A Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC
Yan Zhong, Jingfeng Liu, Wenwen Lin, Tian Peng, Lingfang Gao, Lan Shen, Ping Wang, Zhiyan Hu, Ting Long, Zuguo Li, Jingquan Liu
Int. J. Biol. Sci. 2025; 21(10): 4334-4352. doi:10.7150/ijbs.111032
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Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade
Zhangzhen Du, Yongqi Zhao, Ke Zhang, Qiaozhen Qin, Changyi Luo, Jiamei Wu, Heyang Zhang, Shuirong Liu, Zhenhua Xu, Jing Zheng, Shuli Fan, Xiaoxia Jiang, Xu Li, Yan Wang
Int. J. Biol. Sci. 2025; 21(10): 4353-4373. doi:10.7150/ijbs.105560
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FABP7-mediated lipid-laden macrophages drive the formation of pre-metastatic niche and liver metastasis
Shaowan Xu, Xin Peng, Zhenfang Wang, Chenchen Le, Xiangkun Wu, Zhicheng Zeng, Sisi Zeng, Ceng Zhang, Mingxing Qiu, Xin Zou, Hongxia Zhang, Feifei Wang, Wei Kang, Yanqing Ding, Li Liang
Int. J. Biol. Sci. 2025; 21(10): 4388-4409. doi:10.7150/ijbs.110750
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BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma
Lei Li, Zixi Wang, Bohan Ma, Qi Ye, Yuzeshi Lei, Mingming Lu, Leihong Ye, Jialu Kang, Wenyue Huang, Shan Xu, Ke Wang, Yule Chen, Jing Liu, Yang Gao, Chenji Wang, Jian Ma, Lei Li
Int. J. Biol. Sci. 2025; 21(10): 4410-4427. doi:10.7150/ijbs.115032
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Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis
Hao Chen, Yujia Cui, Jiazhou Li, Mengmeng Duan, Caixia Pi, Xuedong Zhou, Jing Xie
Int. J. Biol. Sci. 2025; 21(10): 4428-4449. doi:10.7150/ijbs.110133
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Nanog overexpression enhances the therapeutic efficacy of ADMSCs in AMI rats via the upregulation of JAK/STAT3 signaling and cyclin-mitochondrial expression
Hsu-Ting Yen, David Kwan Ru Huang, Xian-Wu Lan, Jui-Ning Yeh, Yi-Ling Chen, Chi-Ruei Huang, Yi-Ting Wang, Hon-Kan Yip, Pei-Hsun Sung, Sheung-Fat Ko
Int. J. Biol. Sci. 2025; 21(10): 4450-4466. doi:10.7150/ijbs.112824
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Amlexanox Ameliorates Traumatic Brain Injury by Restoring Autophagy-Lysosomal Function via cAMP Signaling Modulation
Seo Young Woo, Min Kyu Park, A Ra Kho, Hyun Wook Yang, Hyun Ho Jung, Jaewoo Shin, Minwoo Lee, Ha Na Kim, Jae Young Koh, Bo Young Choi, Sang Won Suh
Int. J. Biol. Sci. 2025; 21(10): 4467-4484. doi:10.7150/ijbs.111216
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The glucose sensor NSUN2-m5C modification regulates tumor-immune glucose metabolism reprogramming to drive hepatocellular carcinoma evolution
Jing He, Boqiang Liu, Weijun Zhao, Hao Shen, Yi Wang, Weiqi Li, Chenqi Jin, Yifan Wang, Xiujun Cai, Liang Shi
Int. J. Biol. Sci. 2025; 21(10): 4529-4548. doi:10.7150/ijbs.115610
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LncRNA SLC7A11AR promotes lung adenocarcinoma progression by inhibiting ferroptosis via promoting SLC7A11 expression
Haoqing Zhai, Xudong Xiang, Jun Pu, Xiaoqun Niu, Jie Gao, Dengcai Mu, Jia Du, Yao Li, Laihao Qu, Baiyang Liu, Yongbin Chen, Cuiping Yang
Int. J. Biol. Sci. 2025; 21(10): 4549-4566. doi:10.7150/ijbs.112233
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Ferritinophagy activation states determine the susceptibility to ferroptosis of macrophages in bone marrow and spleen
Xin Lai, Aimin Wu, Yao Liu, Chen Liu, Junzhou Chen, Ke Gu, Bing Yu, Hui Yan, Junqiu Luo, Ping Zheng, Jie Yu, Daiwen Chen
Int. J. Biol. Sci. 2025; 21(10): 4567-4585. doi:10.7150/ijbs.114545
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Novel glycoprotein SBSPON suppressed bladder cancer through the AKT signal pathway by inhibiting HSPA5 membrane translocation
Beibei Ni, Shi Li, Lan Zhao, Lin Gao, Liya Luo, Junwen Zhang, Xina Xie, Yuqi Zhu, Wei Yang, Shasha Min, Yan Wang, Xianxin Li, Zhiming Cai, John R. Speakman, Zesong Li
Int. J. Biol. Sci. 2025; 21(10): 4586-4603. doi:10.7150/ijbs.109973
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Tissue Factor Pathway Inhibitor 2 Enhances Hepatocellular Carcinoma Chemosensitivity by Activating CCAR2-GADD45A-Mediated DNA Damage Repair
Hongzhong Zhou, Liwen Zhu, Yajun Zhang, Lichan Chen, Dong-Mei Gou, Haohua Zhang, Rongmao Hua, Jianning Song, Chuanghua Qiu, Fu-Wen Yao, Xiafei Wei, Dayong Gu, Yong Xu
Int. J. Biol. Sci. 2025; 21(10): 4629-4646. doi:10.7150/ijbs.111142
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SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis
Qiwen Yu, Dongjing Yang, Binli Ran, Jie Pan, Yaodong Song, Mengwei Cui, Qianqian He, Chaopeng Mei, Haifeng Wang, Huihui Li, Guanghui Li, Yinuo Meng, Fazhan Wang, Wenzhi Guo, Changju Zhu, Sanyang Chen
Int. J. Biol. Sci. 2025; 21(10): 4663-4682. doi:10.7150/ijbs.114510
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Novel High-Throughput Screen Identified S100A4 Inhibitors for Anti-Metastatic Therapy
Paul Curtis Schöpe, Nina Heisterkamp, Devin Schütz, Guido Mastrobuoni, Kerstin Putzker, Ulrike Uhrig, Wolfgang Walther, Stefan Kempa, Marc Nazaré, Dennis Kobelt, Ulrike Stein
Int. J. Biol. Sci. 2025; 21(10): 4683-4700. doi:10.7150/ijbs.113805
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Reviews

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Beyond polarization: macrophage senescence in immunoregulation and cancer therapy
Mei Song, Lifen Zhang, Xiaofeng Dai, Shiliang Ji, Jiayin Shen, Weiling He
Int. J. Biol. Sci. 2025; 21(10): 4312-4333. doi:10.7150/ijbs.115921
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Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease
Hua Miao, Shui-Juan Zhang, Xin Wu, Ping Li, Ying-Yong Zhao
Int. J. Biol. Sci. 2025; 21(10): 4374-4387. doi:10.7150/ijbs.115359
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Cancer patient-derived organoids: Novel models for the study of natural products
Shuxin Liu, Ren Zhang, Yachen Liu, Xian Lin, Jian Chen
Int. J. Biol. Sci. 2025; 21(10): 4485-4503. doi:10.7150/ijbs.114373
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New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets
Kenly Wuputra, Chia-Che Ku, Wen-Hung Hsu, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chih-Yen Chen, Yoshiharu Tanaka, Ying-Chu Lin, Chao-Hung Kuo, Deng-Chyang Wu, Kazunari K. Yokoyama
Int. J. Biol. Sci. 2025; 21(10): 4504-4528. doi:10.7150/ijbs.112869
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Harnessing Natural Products to Surmount Drug Resistance in Gastric Cancer: Mechanisms and Therapeutic Perspectives
QingShui Wang, Fangqin Xue, Yehuda G. Assaraf, Yao Lin
Int. J. Biol. Sci. 2025; 21(10): 4604-4628. doi:10.7150/ijbs.113709
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Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease
Hui Zhao, Jia Guo
Int. J. Biol. Sci. 2025; 21(10): 4647-4662. doi:10.7150/ijbs.112737
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