International Journal of Biological Sciences
ISSN: 1449-2288
Global reach, higher impactVolume 21 (9); 2025
Research Papers
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma
Siqi Zhou, Shiqi Ye, Liang Chen, Qintao Ge, Jiahe Lu, Aihetaimujiang Anwaier, Xi Tian, Zhongyuan Wang, Shuxuan Zhu, Kun Chang, Jianfeng Yang, Tian Li, Hailiang Zhang, Dingwei Ye, Jianfeng Xiang, Wenhao Xu
Int. J. Biol. Sci. 2025; 21(9): 3827-3851. doi:10.7150/ijbs.113737
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APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes
Juan Wang, Jijia Hu, Hongtu Hu, Qian Guan, Zijing Zhu, Qian Yang, Guohua Ding
Int. J. Biol. Sci. 2025; 21(9): 3852-3866. doi:10.7150/ijbs.109220
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Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification
Jiwon Ahn, Kajung Ryu, Hyerin Kim, Hwi Won Seo, Minsu Jang, Seung-Hyun Kim, Yunho Park, Myung Jin Son, Ho-Joon Lee, Ok-Seon Kwon, Kyung-Sook Chung
Int. J. Biol. Sci. 2025; 21(9): 3867-3885. doi:10.7150/ijbs.108268
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Unlocking the Puzzle of Mammalian Transfection: The Role of the RNA-sensing-Mediated Interferon Response in the Cellular Defense Against Foreign DNA Intrusion
Xiaoyu Li, Yicen Zhou, Jie Wei, Wei Sun, Ligang Fan, Jian Yan
Int. J. Biol. Sci. 2025; 21(9): 3886-3900. doi:10.7150/ijbs.107510
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Epithelial DPP4 promotes Ang II-driven renal fibrosis by targeting ACE2 activity in the renin-angiotensin system
Yingying Zhang, Ruizhi Tan, Lehao Wu, Dan Zhao, Cheng Zhong, Chenggong Luo, Jeff Yat-Fai Chung, Patrick Ming-Kuen Tang, Chen Yu
Int. J. Biol. Sci. 2025; 21(9): 3901-3916. doi:10.7150/ijbs.106418
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Melatonin Ameliorate neuroinflammation in activated microglia through the Aryl hydrocarbon-Nrf2 axis
Meei-Ling Sheu†, Cheng-Ning Yang, Liang-Yi Pan, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Ying Ju Chen, Hong-Shiu Chen†, Hung-Chuan Pan
Int. J. Biol. Sci. 2025; 21(9): 3917-3933. doi:10.7150/ijbs.105081
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WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability
Danyang Fan, Yilong Yao, Chao Yan, Fanqinyu Li, Yalan Yang, Bingkun Xie, Zhonglin Tang
Int. J. Biol. Sci. 2025; 21(9): 3934-3948. doi:10.7150/ijbs.102309
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Signature-based repurposed drugs resemble the inhibition of TGFβ-induced NDRG1 as potential therapeutics for triple-negative breast cancer
Araceli López-Tejada, Jose L. Blaya-Cánovas, Francisca E. Cara, Jesús Calahorra, César Ramírez-Tortosa, Isabel Blancas, Violeta Delgado-Almenta, Fabiola Muñoz-Parra, Marta Ávalos-Moreno, Ana Sánchez, Adrián González-González, Juan A. Marchal, Carmen Griñán-Lisón, Sergio Granados-Principal
Int. J. Biol. Sci. 2025; 21(9): 3949-3967. doi:10.7150/ijbs.112645
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Multi-cohort validation of a lipid metabolism and ferroptosis-associated index for prognosis and immunotherapy response prediction in hormone receptor-positive breast cancer
Cheng Zeng, Jiani Wang, Shen Zhao, Yuhan Wei, Yalong Qi, Shuning Liu, Yuanyi Wang, Hewei Ge, Xiaoqi Yang, Yujing Tan, Yizhou Jiang, Haili Qian, Fei Ma
Int. J. Biol. Sci. 2025; 21(9): 3968-3992. doi:10.7150/ijbs.113213
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Protein Arginine Methyltransferase 1-mediated Histone H4R3 Dimethyl Asymmetric enhances Epidermal Growth Factor Receptor signaling to promote Peritoneal Fibrosis
Hui Chen, Yingfeng Shi, Jinqing Li, Qin Zhong, Xiaoyan Ma, Yan Hu, Yishu Wang, Daofang Jiang, Xialin Li, Shasha Zhang, Shougang Zhuang, Na Liu
Int. J. Biol. Sci. 2025; 21(9): 4010-4026. doi:10.7150/ijbs.114037
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Exogenous SPD inhibits trastuzumab-mediated cardiomyocyte pyroptosis through SIRT3-regulated mitochondrial quality control
Xue Yu, Yan Yang, Tianzuo Chen, Qianbing Wang, Zitong Wang, Xi Gao, Qianxue Wang, Jinxiang Guo, Yuqin Wang, Yajie Zhao, Shilin Wang, Wei Lu, Xing Luo, Tielei Gao, Jiayuan Kou, Hong Li, Liming Yang
Int. J. Biol. Sci. 2025; 21(9): 4027-4050. doi:10.7150/ijbs.110580
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Arsenic disrupts H3K9me3 and H3K27me3 balance by biasing PRC2.1 and PRC2.2 activity via PALI1 inhibition in carcinogenesis
Haoyan Ji, Millie Elangbam, Yiran Qiu, Jessica Bamrah, Wenxuan Zhang, Aashna Pawar, Chitra Thakur, Fei Chen, Ziwei Wang
Int. J. Biol. Sci. 2025; 21(9): 4069-4080. doi:10.7150/ijbs.115605
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Promoter Hyper-methylation of ZNF662 Restrains its Tumor Suppressing Function in Triple-Negative Breast Cancer Through Regulating NGF Signaling Axis
Renjie Yu, Xi Peng, Zhaobo Cheng, Yue Wu, Huan Rong, Lin Yi, Jing Ran, Chaoqun Deng, Xiangyi Zhou, Ruijie Ming, Ningning Zhang, Xiaoyu Liu, Xiaohua Zeng, Yun Xiao, Xue Wang, Yongzhong Wu, Bo Qin, Tingxiu Xiang
Int. J. Biol. Sci. 2025; 21(9): 4081-4097. doi:10.7150/ijbs.102940
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Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070
Tien-Huang Lin, Shan-Chi Liu, Yuan-Li Huang, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Yi-Chin Fong, Hsi-Chin Wu, An-Chen Chang, Yen-You Lin, Chih-Hsueh Lin, Chih-Hsin Tang
Int. J. Biol. Sci. 2025; 21(9): 4117-4128. doi:10.7150/ijbs.113161
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Reviews
Deubiquitinating enzymes: Key regulators of ferroptosis and pyroptosis and novel targets for cancer intervention
Sheng-Kai Hsu, I-Ying Kuo, Pin-Yuan Lin, Chon-Kit Chou, Ching-Chung Ko, Wen-Tsan Chang, Chien-Chih Chiu
Int. J. Biol. Sci. 2025; 21(9): 3993-4009. doi:10.7150/ijbs.111867
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Interaction of Nanomaterials with Nucleic Acids and Their Applications in Nucleic Acid Analysis
Jiale Wang, Kai Li, Fukai Li, Xinran Li, Jian Zhou, Mengrui Yang, Xiao Zhang, Mengyu Wang, Liang Li
Int. J. Biol. Sci. 2025; 21(9): 4051-4068. doi:10.7150/ijbs.113309
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Orchestration of Tumor-Associated Macrophages in the Tumor Cell-Macrophage-CD8+ T Cell Loop for Cancer Immunotherapy
Lin He, Paul Kwong-Hang Tam, Chu-Xia Deng
Int. J. Biol. Sci. 2025; 21(9): 4098-4116. doi:10.7150/ijbs.115932
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